Global Advanced Metals and Croom Medical Collaborate to Offer Tantalum Additive Manufacturing Capability

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Tantalum Powder Printed Lattice

Printed lattice from Croom Medical on a GE M2 Series 5 printer using Spherical Tantalum Powder from Global Advanced Metals

Global Advanced Metals (USA) and Croom Medical (Ireland) are collaborating to establish a turnkey tantalum-based additive manufacturing (AM) platform. A laser powder bed fusion GE M2 Series 5 printer has been installed within Croom's facility, with the printer being fully dedicated to the use of GAM's tantalum AM powder. With Croom's years of successful contract manufacturing experience, the tantalum print capability is being offered by Croom as a contract manufacturing solution, bringing the advantages of tantalum to the medical device, aerospace, and related markets. 

Global Advanced Metals (GAM), headquartered in Massachusetts, USA, has more than a 70-year history of innovation and manufacturing of high-grade tantalum powders for use in electronics and other applications. GAM has more recently developed a spheriodized tantalum powder, a necessary form for use in "printing" of tantalum parts.

Based in County Limerick, Ireland, Croom Medical (Croom) has operated for more than 35 years providing contract manufacturing services to medical device (and other) OEMs. In recent years, Croom has developed an extensive capability in AM technology in collaboration with a number of academic and state-sponsored institutions and has successfully manufactured more than 20,000 devices by AM technology.

AM has a number of key advantages over traditional subtractive manufacturing processes.  AM intrinsically uses less material than subtractive methods, produces more complex and lightweight part geometries, can be used for rapid prototyping, and manufactured parts can be ultimately printed in close proximity to point of use.

GAM and Croom are initially targeting the contract manufacturing of medical implants and components that would benefit from the enhanced performance offered by tantalum. Multiple papers cite advantages of tantalum-based implants compared to existing implant materials, including improved biocompatibility (reduced clotting), enhanced bone in-growth, tolerable to higher stress, and produces high surface friction promoting implant stability1,2,3,4,5. These benefits should lower the rate of surgery revisions, thus avoiding patient discomfort and unnecessary added surgery costs. Although use of tantalum in AM applications is relatively new, tantalum has been extensively and successfully used for many years in in-vivo surgical devices such as surgical staples, dental implants, and hip and knee implants. GAM and Croom believe that using AM technology to develop these devices will enable production of complex, porous, strong and lightweight structures.

As part of this collaboration, GAM will provide spherical tantalum powder, produced in its Boyertown, Pennsylvania, plant and derived from ethically and conflict-free-sourced tantalum raw material. The team at Croom will manufacture devices and components for customers using a recently acquired GE M2 printer 100% dedicated to the project and material. In a circular manufacturing cycle, tantalum raw material that cannot be reused in this AM process will be recycled back to GAM's Pennsylvania facility. GAM's raw material and tantalum powder expertise, Croom's decades-long experience manufacturing, finishing and testing devices to medical device standards, and Croom's proximity and relationship with many of the top device OEMs situated in Ireland, positions this collaboration for long-term success. 

Andrew O'Donovan, CEO of Global Advanced Metals, added, "GAM is thrilled to work with such an experienced and trusted company as Croom Medical. In recent years, GAM has worked to enhance the production of ultra-pure spherical tantalum powder for 3D printing. GAM views the intrinsic purity and properties of tantalum as a wonderful fit for next generation implants and Croom is the company with the experience, capability and long-established customer relationships to bring this to market."

1. Matsuno H, Yokoyama A, Watari F, Motohiro U, Kawasaki T., Biocompatibility and osteogenesis of refractory metal implants, titanium, hafnium, niobium, tantalum and rhenium. Biomaterials. 2001 ;22:1253-1262.

2. Miyazaki T, et.al., Biomaterials. 2002;23:827-32; Balla V, et.al., Acta  Biomater. 2009

3. Hacking SA, Bobyn JD, Toh K, Tanzer M, Krygier JJ. Fibrous tissue ingrowth and attachment to porous tantalum. J Biomed Mater Res. 2000; 52:631-638

4. Hacking S, et.al., J Biomed Mater Res. 2000;52:631-638; Balla, V., et.al., Acta Biomater. 2010 Aug; 6(8): 3349-3359;   Levine BR, Sporer S, Poggie RA, Valle CJD, Jacobs JJ. Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials. 2006; 27:4671-4681.

5. Sungail, C., Abid, A., Metal Powder Report, online 25 March 2019

ABOUT GAM

A leading conflict-free tantalum producer, GAM has exclusive rights to the world's largest industrial resources of tantalum ore located in Western Australia, where GAM extracts tantalum as a co-product of lithium mining. GAM produces conflict-free tantalum powders and metallurgical products at its Pennsylvania, USA, and Aizu, Japan, plants for a range of industries, including electronics, aerospace, defense and medical. GAM's facilities in Japan and the USA were first declared "Conflict Free" in 2010 under the, now called, Responsible Minerals Assurance Program and have maintained conformance to this program every year.

Contact Information:
Gordon Smith
Chief Technology Officer
[email protected]


Original Source: Global Advanced Metals and Croom Medical Collaborate to Offer Tantalum Additive Manufacturing Capability

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New Study Shows Copper-Silver Ionization is Effective for Legionella Control

Legionnaires' disease cases have increased nearly tenfold in recent decades, leading to thousands of hospitalizations and deaths. Outbreaks are linked to Legionella, a bacteria found in potable water systems in large facilities like hospitals, multi-family buildings, resorts, and office buildings. A recently published study shows that copper-silver ionization effectively controls Legionella in building water systems to prevent Legionnaires' disease.

New Study Shows Copper-Silver Ionization is Effective for Legionella Control
Copper-Silver Ionization System

A copper-silver ionization system installed in a building to prevent Legionella in the potable water supply.

A new study published in the American Water Works Association (AWWA) Water Science journal shows that copper-silver ionization effectively controls Legionella in building water systems. The study, conducted by Dr. Mark LeChevallier with technical and financial support from LiquiTech, examines more than 80 sources of research studies and related literature to analyze the efficacy of copper-silver ionization as a water treatment solution. Dr. LeChevallier concludes "that use of copper-silver ionization to control Legionella and other opportunistic pathogens is highly effective when the units are properly designed, maintained, and operated."

Legionnaires' disease cases have increased nearly tenfold in recent decades, leading to thousands of hospitalizations. Those who catch Legionnaires' disease experience a severe form of pneumonia caused by Legionella, a bacteria found in poorly maintained water systems.

Studies show that Legionella is responsible for about two-thirds of all disease outbreaks from drinking water and the cause of all documented deaths attributed to drinking water-associated infections.

Historically, outbreaks were linked to cooling tower systems. As our understanding of Legionella has advanced over recent decades, most outbreaks are now connected to potable water systems in large facilities, such as hospitals, long-term healthcare facilities, resorts, and office buildings. It's estimated that 54% of all potable building water systems have some level of Legionella present.

Plumbing codes and regulations have been developed to standardize the design, structure, and management of building water systems to prevent waterborne diseases. However, based on the studies cited in this article and elsewhere, there is a need for supplemental treatment of building water systems.

One such supplemental treatment is copper-silver ionization, a chemical-free disinfection solution for potable water systems. It releases copper and silver ions into the building's water system to destroy waterborne pathogens like Legionella

Copper-silver ionization is not a new water treatment option. Silver ionization was used in the 1960s by NASA for the sanitation of water on spacecraft. In the 1980s, copper-silver ionization was used in swimming pools as an alternative to chlorine.

Later, in 1994, copper-silver ionization was the first reported effective treatment for controlling Legionella in a hospital. Today, copper-silver ionization is used to prevent waterborne pathogens in a variety of buildings with complex water systems.

Although copper-silver ionization is a low-cost and chemical-free option for water disinfection, the system must be designed properly and used in the appropriate applications to achieve optimal results. Crucial to its effectiveness is identifying and responding to abnormalities in water usage patterns and chemistry. 

Dr. LeChevallier, a drinking water research scientist with a Ph.D. in Microbiology, examined literature and studies related to copper-silver ionization system design, maintenance, and operations, and the impact water chemistry has on its performance. In addition to authoring more than 300 research papers, Dr. LeChevallier is a member of the Drinking Water Subcommittee of the Science Advisory Board of the United States Environmental Protection Agency (US EPA), a past member of the Water Science Technology Board of the National Academies of Science, and the past Chair of the AWWA Water Science & Research Division.

In his recently published study, Dr. LeChevallier explained, "These water quality and operational characteristics must be properly addressed to assure that the highest disinfection efficacy is obtained through copper-silver ionization."

He reviewed research and related literature to investigate the mechanisms of copper and silver disinfection. Copper-silver ionization works by treating water through electrolysis. An electric current is applied to a copper and silver bar to produce and release positively charged ions. These copper and silver ions then find microorganisms in the water with a negative charge, like Legionella. The copper ions bond to the negative walls of the microorganisms, disrupting cell wall permeability and the absorption of life-sustaining nutrients. This disruption to the cell wall allows the silver ions to enter and destroy the core of the bacteria, thus making it impossible to survive. 

Dr. LeChevallier cited studies showing that copper and silver can work as biocides independently or together. One study emphasized that combined treatment with copper and silver was associated with decreased incidence of Legionella and a faster reduction of bacteria than copper or silver alone.  

In addition to copper-silver ionization being considered an effective supplemental method for water treatment by researchers, the US EPA has recognized both copper and silver as metallic antimicrobial agents. Studies show that copper-silver ionization is effective against many waterborne pathogens, including Legionella, Nontuberculous Mycobacterium, Pseudomonas, Stenotrophomonas, Acinetobacter, and fungi.

While the issue of copper-silver resistance was discussed in portions of the literature that Dr. LeChevallier reviewed, it's important to note that there was no evidence of it occurring with Legionella. Copper-silver resistance, where pathogens can continue to grow and thrive even in the presence of copper and silver, was only observed with E. coli and Salmonella.

During his investigation, Dr. LeChevallier found that the design, operation, and maintenance of copper-silver ionization systems are critical to their effective functionality. In his published paper, he explained that copper-silver ionization will act as a water disinfectant; however, the proper engineering and operation of the system are integral to its success.

Essential components of the copper-silver ionization system include the electrodes, flow cells, power supply, control panel, flow meter, and web interface. Each component must be operated and maintained for copper-silver ionization to be most effective. 

"Buyers of [copper-silver ionization] systems should pay attention to the design and configuration of the electrodes - particularly as they wear. The construction of the flow cell and the adequacy of the power supply are important to deliver the necessary amperage to achieve the target copper and silver concentrations. Copper and silver doses should be flow paced and can be remotely monitored with a web-based interface," said Dr. LeChevallier.

Additionally, Dr. LeChevallier cautioned that water quality can impact copper-silver ionization as a water treatment. He explained that water chemistry, physiochemical, and environmental factors can influence the efficacy of copper-silver ionization if not considered and managed correctly. 

Specific factors to consider include temperature, oxygen levels in the water, flow, pH levels, and levels of biofilm, sediment, and other chemicals that can impact the performance of copper-silver ionization. He stressed that these factors must be considered during planning, commissioning, and system operations for copper-silver ionization to be successful. 

Dr. LeChevallier cited several case studies where copper-silver ionization was implemented in a building water system with positive outcomes. He explained that University of Pittsburgh researchers Dr. Stout and Dr. Yu found that copper-silver ionization is a viable proactive strategy for long-term Legionella control, specifically for healthcare facilities. 

The studies collected data from 16 hospitals with copper-silver ionization systems over the course of five to 11 years. These studies found that 50% of the hospitals had not reported any indications of Legionella, and 43% had no indications for another five years.

In addition to the promising implementation of copper-silver ionization at hospitals, other case studies found benefits in multi-family buildings, hotels, and other specialized hospitals, including children's and veterans' hospitals.

Summarizing his findings, Dr. LeChevallier concluded, "This study has shown that [copper-silver ionization] can be effectively used for management of Legionella and other waterborne pathogens through the installation of a properly designed and maintained [copper-silver ionization] system and the details of the engineering and operation of the system are important to ensure the consistent delivery of copper and silver ions at their target levels."

About LiquiTech

For more than 30 years, LiquiTech has partnered with businesses worldwide to provide chemical-free, sustainable water treatment solutions. Their highly engineered approach brings together the right combination of products, services, and expertise to solve the most challenging water quality issues and help businesses get the most out of their water-bearing equipment. With more than 3,000 installations, LiquiTech is the worldwide leader in smart, clean solutions for water treatment. Learn more at liquitech.com.

Contact Information:
Kelsey Raftery
Director of Marketing
[email protected]
847.738.0933


Original Source: New Study Shows Copper-Silver Ionization is Effective for Legionella Control

Let’s Talk Interactive, Inc. Ranks 50th in Financial Times’ The Americas’ Fastest-Growing Companies in 2023

An innovator in virtual care, LTI is one of the fastest-growing companies in the Americas with a 1,256 percent growth rate between 2018 and 2021.

Let's Talk Interactive, Inc. (LTI), a leader in customizable virtual care solutions, is ranked number 50 in the Financial Times' fourth edition of The Americas' Fastest-Growing Companies, a ranking and special report on high-growth businesses in North, Central, and South America, based on companies with the strongest revenue growth between 2018 and 2021.

"It's an honor for Let's Talk Interactive, Inc. to be named among the Financial Times' fastest-growing companies," CEO and Founder Art Cooksey said. "This comes on the heels of being recognized by Inc magazine as well, reinforcing our standing as a company that has a high growth potential."

For this special report, the Financial Times examined over 7,000 public companies across 20 countries. The data was collected via desk research in official sources like publicly available earning presentations, investor relations, websites, and annual reports.

"We continue to innovate in the virtual care sector, one that has experienced challenges and consolidation recently," Cooksey said. LTI offers healthcare providers a HIPAA-compliant telehealth platform and medical device integrations that increase patient access to quality healthcare.

LTI's new enterprise telehealth platform, TrustVideo, is customizable with any workflow, can integrate with any EMR/EHR, and serves any medical use case. LTI's Medcart software pairs with medical hardware such as telemedicine carts, soft packs, and peripherals, which are all part of LTI's overall custom digital healthcare solutions that enable providers to evaluate patients remotely.

"We are continuing global growth with our partners, AWS, Ingram Micro, Liberty Wesco, and continue to focus on our mission to expand access to healthcare," Cooksey said. "We are experiencing tremendous growth and look forward to continuing to provide excellent telemedicine solutions to our customers."

As a leader in creating innovative digital healthcare solutions, the company's award-winning HIPAA-compliant software is enhanced with custom web and software development as well as provider network solutions that improve access to care at any time, from anywhere in the world.

About Let's Talk Interactive, Inc.

Let's Talk Interactive, Inc. is an innovator in telehealth that has developed the most complete and configurable HIPAA-compliant telemedicine platform in the world. Through proprietary telehealth software, medical hardware, and provider network solutions, LTI gives those in need instant access to care. Headquartered in Charlotte, NC, the company ranked No. 496 on the 2022 Inc. 5000 annual list of fastest-growing companies. LTI is committed to providing innovative solutions for patients and healthcare providers in the post-COVID-19 era. For more information about Let's Talk Interactive, visit www.letstalkinteractive.com.

Contact Information:
Caitlin Wolf
PR and Communications Executive, LTI
[email protected]
980-220-3777


Original Source: Let's Talk Interactive, Inc. Ranks 50th in Financial Times' The Americas' Fastest-Growing Companies in 2023